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“Microglial nodules” and “newly forming lesions” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model

BACKGROUND: Although the precise mechanism of initial lesion development in multiple sclerosis (MS) remains unclear, two different neuropathological findings have been reported as a potential early pathology of MS: “microglial nodules” and “newly forming lesions”, both of which contain neither T cel...

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Detalhes bibliográficos
Publicado no:BMC Neurol
Main Authors: Sato, Fumitaka, Martinez, Nicholas E., Stewart, Elaine Cliburn, Omura, Seiichi, Alexander, J. Steven, Tsunoda, Ikuo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619492/
https://ncbi.nlm.nih.gov/pubmed/26499989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-015-0478-y
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