“Microglial nodules” and “newly forming lesions” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model

BACKGROUND: Although the precise mechanism of initial lesion development in multiple sclerosis (MS) remains unclear, two different neuropathological findings have been reported as a potential early pathology of MS: “microglial nodules” and “newly forming lesions”, both of which contain neither T cel...

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Published in:BMC Neurol
Main Authors: Sato, Fumitaka, Martinez, Nicholas E., Stewart, Elaine Cliburn, Omura, Seiichi, Alexander, J. Steven, Tsunoda, Ikuo
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619492/
https://ncbi.nlm.nih.gov/pubmed/26499989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-015-0478-y
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