The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis

Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced. HepG2 (p53wt) and Hep...

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Veröffentlicht in:Cell Oncol
Hauptverfasser: Di Fazio, Pietro, Schneider-Stock, Regine, Neureiter, Daniel, Okamoto, Kinya, Wissniowski, Till, Gahr, Susanne, Quint, Karl, Meissnitzer, Matthias, Alinger, Beate, Montalbano, Roberta, Sass, Gabriele, Hohenstein, Bernd, Hahn, Eckhart G., Ocker, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: IOS Press 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619232/
https://ncbi.nlm.nih.gov/pubmed/20208142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CLO-2010-0511
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