Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion with repeats of VP16 activator domains can efficiently activate human genes involved in pluripotency in various cell types. This activator in...

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Publicado en:Stem Cell Reports
Autores principales: Balboa, Diego, Weltner, Jere, Eurola, Solja, Trokovic, Ras, Wartiovaara, Kirmo, Otonkoski, Timo
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618656/
https://ncbi.nlm.nih.gov/pubmed/26352799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.08.001
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