Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

CRISPR activation (CRISPRa) has revealed great potential as a tool to modulate the expression of targeted cellular genes. Here, we successfully applied the CRISPRa system to trigger the Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation in latently infected cells by selectively activating O...

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Bibliographische Detailangaben
Veröffentlicht in:Viruses
Hauptverfasser: Elbasani, Endrit, Falasco, Francesca, Gramolelli, Silvia, Nurminen, Veijo, Günther, Thomas, Weltner, Jere, Balboa, Diego, Grundhoff, Adam, Otonkoski, Timo, Ojala, Päivi M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7552072/
https://ncbi.nlm.nih.gov/pubmed/32867368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12090952
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