Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress

Maintaining genomic integrity during DNA replication is essential for stem cells. DNA replication origins are licensed by the MCM2–7 complexes, with most of them remaining dormant. Dormant origins (DOs) rescue replication fork stalling in S phase and ensure genome integrity. However, it is not known...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Ge, Xin Quan, Han, Jinah, Cheng, Ee-Chun, Yamaguchi, Satoru, Shima, Naoko, Thomas, Jean-Leon, Lin, Haifan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618655/
https://ncbi.nlm.nih.gov/pubmed/26190528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.06.002
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