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In silico identified targeted inhibitors of P-glycoprotein overcome multidrug resistance in human cancer cells in culture
Failure of cancer chemotherapies is often linked to the over expression of ABC efflux transporters like the multidrug resistance P-glycoprotein (P-gp). P-gp expression in cells leads to the elimination of a variety of chemically unrelated, mostly cytotoxic compounds. Administration of chemotherapeut...
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| Publicat a: | Pharmacol Res Perspect |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley & Sons, Ltd
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618641/ https://ncbi.nlm.nih.gov/pubmed/26516582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.170 |
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