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Prolonged inhibition of P-glycoprotein after exposure to chemotherapeutics increases cell mortality in multidrug resistant cultured cancer cells

One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance (MDR) phenomenon results in failed therapies and...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nanayakkara, Amila K., Vogel, Pia D., Wise, John G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555590/
https://ncbi.nlm.nih.gov/pubmed/31173617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217940
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