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Prolonged inhibition of P-glycoprotein after exposure to chemotherapeutics increases cell mortality in multidrug resistant cultured cancer cells

One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance (MDR) phenomenon results in failed therapies and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nanayakkara, Amila K., Vogel, Pia D., Wise, John G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555590/
https://ncbi.nlm.nih.gov/pubmed/31173617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217940
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