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Prolonged inhibition of P-glycoprotein after exposure to chemotherapeutics increases cell mortality in multidrug resistant cultured cancer cells

One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance (MDR) phenomenon results in failed therapies and...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Nanayakkara, Amila K., Vogel, Pia D., Wise, John G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555590/
https://ncbi.nlm.nih.gov/pubmed/31173617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217940
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