Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site

Glutamate homeostasis in the brain is maintained by glutamate transporter mediated accumulation. Impaired transport is associated with several neurological disorders, including stroke and amyotrophic lateral sclerosis. Crystal structures of the homolog transporter GltPh from Pyrococcus horikoshii re...

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Publicado en:PLoS Comput Biol
Autores principales: Venkatesan, SanthoshKannan, Saha, Kusumika, Sohail, Azmat, Sandtner, Walter, Freissmuth, Michael, Ecker, Gerhard F., Sitte, Harald H., Stockner, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618328/
https://ncbi.nlm.nih.gov/pubmed/26485255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004551
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