Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site

Glutamate homeostasis in the brain is maintained by glutamate transporter mediated accumulation. Impaired transport is associated with several neurological disorders, including stroke and amyotrophic lateral sclerosis. Crystal structures of the homolog transporter GltPh from Pyrococcus horikoshii re...

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Udgivet i:PLoS Comput Biol
Main Authors: Venkatesan, SanthoshKannan, Saha, Kusumika, Sohail, Azmat, Sandtner, Walter, Freissmuth, Michael, Ecker, Gerhard F., Sitte, Harald H., Stockner, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618328/
https://ncbi.nlm.nih.gov/pubmed/26485255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004551
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