The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity

Mitochondria need to be juxtaposted to phagosomes to synergistically produce ample reactive oxygen species (ROS) in phagocytes for pathogens killing. However, how phagosomes transmit signal to recruit mitochondria remains unclear. Here, we report that the kinases Mst1 and Mst2 function to control RO...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Geng, Jing, Sun, Xiufeng, Wang, Ping, Zhang, Shihao, Wang, Xiaozhen, Wu, Hongtan, Hong, Lixin, Xie, Changchuan, Li, Xun, Zhao, Hao, Liu, Qingxu, Jiang, Mingting, Chen, Qinghua, Zhang, Jinjia, Li, Yang, Song, Siyang, Wang, Hong-Rui, Zhou, Rongbin, Johnson, Randy L., Chien, Kun-Yi, Lin, Sheng-Cai, Han, Jiahuai, Avruch, Joseph, Chen, Lanfen, Zhou, Dawang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618176/
https://ncbi.nlm.nih.gov/pubmed/26414765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3268
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