A Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function

BACKGROUND: The use of microsomal triglyceride transfer protein (MTP) inhibitors is limited to severe hyperlipidemias due to associated hepatosteatosis and gastrointestinal adverse effects. Comprehensive knowledge about the structure-function of MTP might help design new molecules that avoid steatos...

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Detalles Bibliográficos
Publicado en:Circ Cardiovasc Genet
Main Authors: Walsh, Meghan T., Iqbal, Jahangir, Josekutty, Joby, Soh, James, Di Leo, Enza, Özaydin, Eda, Gündüz, Mehmet, Tarugi, Patrizia, Hussain, M. Mahmood
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618089/
https://ncbi.nlm.nih.gov/pubmed/26224785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001106
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