Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer

Assessing the extent of phosphoinositol 3-kinase (PI3K) pathway activity in cancer is vital to predicting sensitivity to PI3K-targeting drugs but the best biomarker of PI3K pathway activity in archival tumor specimens is unclear. Here PI3K pathway activation was assessed, in clinical tissue from 1,0...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Martin, Neil E, Gerke, Travis, Sinnott, Jennifer A, Stack, Edward C, Andrén, Ove, Andersson, Swen-Olof, Johansson, Jan-Erik, Fiorentino, Michelangelo, Finn, Stephen, Fedele, Giuseppe, Stampfer, Meir, Kantoff, Philip W, Mucci, Lorelei A, Loda, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618038/
https://ncbi.nlm.nih.gov/pubmed/26124442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0569
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