Streptococcus pyogenes Sortase Mutants Are Highly Susceptible to Killing by Host Factors Due to Aberrant Envelope Physiology

Cell wall anchored virulence factors are critical for infection and colonization of the host by Gram-positive bacteria. Such proteins have an N-terminal leader sequence and a C-terminal sorting signal, composed of an LPXTG motif, a hydrophobic stretch, and a few positively charged amino acids. The s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Raz, Assaf, Tanasescu, Ana-Maria, Zhao, Anna M., Serrano, Anna, Alston, Tricia, Sol, Asaf, Bachrach, Gilad, Fischetti, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617865/
https://ncbi.nlm.nih.gov/pubmed/26484774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140784
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