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Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

BACKGROUND: The transcription factor farnesoid X receptor (FXR) governs bile acid and energy homeostasis, is involved in inflammation, and has protective functions in the liver. In the present study we investigated the effect of Fxr deficiency in mouse precision cut liver slices (PCLS) exposed to a...

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Detaylı Bibliyografya
Yayımlandı:BMC Genomics
Asıl Yazarlar: Szalowska, Ewa, Pronk, Tessa E., Peijnenburg, Ad ACM
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617705/
https://ncbi.nlm.nih.gov/pubmed/26482353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-2054-7
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