Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices

Although drug induced steatosis represents a mild type of hepatotoxicity it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models nee...

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Autors principals: Szalowska, Ewa, van der Burg, Bart, Man, Hai-Yen, Hendriksen, Peter J. M., Peijnenburg, Ad A. C. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906077/
https://ncbi.nlm.nih.gov/pubmed/24489787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086795
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