Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides

[Image: see text] Human granulocyte colony-stimulating factor (G-CSF) is an endogenous glycoprotein involved in hematopoiesis. Natively glycosylated and nonglycosylated recombinant forms, lenograstim and filgrastim, respectively, are used clinically to manage neutropenia in patients undergoing chemo...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Roberts, Andrew G., Johnston, Eric V., Shieh, Jae-Hung, Sondey, Joseph P., Hendrickson, Ronald C., Moore, Malcolm A. S., Danishefsky, Samuel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617663/
https://ncbi.nlm.nih.gov/pubmed/26401918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b08754
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker