Synthesis of granulocyte–macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material

Granulocyte–macrophage colony-stimulating factor (GM-CSF) is a medicinally important glycoprotein, used as an immunostimulant following bone-marrow transplant. On the basis of reports of its potential utility as an anticancer vaccine adjuvant, we undertook to develop a synthetic route toward single-...

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Hlavní autoři: Zhang, Qiang, Johnston, Eric V., Shieh, Jae-Hung, Moore, Malcolm A. S., Danishefsky, Samuel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939888/
https://ncbi.nlm.nih.gov/pubmed/24516138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400140111
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