Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair

Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER). DNA lesions are initially detected by NER factors XPC and XPE or stalled RNA polymerases, but only bulky lesions are preferentially repaired by NER. To elucidate substrate specificity in NER, w...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Li, Chia-Lung, Golebiowski, Filip M., Onishi, Yuki, Samara, Nadine L., Sugasawa, Kaoru, Yang, Wei
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617536/
https://ncbi.nlm.nih.gov/pubmed/26384665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.012
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