Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells

Purpose: Doxorubicin is administrated as a single agent in first-line therapy of breast cancer to induce apoptosis in tumor cells. Bax, Bcl-xL, Caspase-8 and 9 proteins are involved in induction of apoptosis. The present study describes Bax, Bcl-xL gene expression and Caspase-8 and 9 protein levels...

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Publicat a:Adv Pharm Bull
Autors principals: Sharifi, Simin, Barar, Jaleh, Hejazi, Mohammad Saeid, Samadi, Nasser
Format: Artigo
Idioma:Inglês
Publicat: Tabriz University of Medical Sciences 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616902/
https://ncbi.nlm.nih.gov/pubmed/26504757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15171/apb.2015.049
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