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T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes

Objective: To investigate the effects of T-2 toxin on expressions of Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 on human chondrocytes. Methods: Human chondrocytes were treated with T-2 toxin (1~20 ng/ml) for 5 d. Fas, p53 and other apoptosis-related proteins such as Bax, Bcl-2, Bcl-xL, caspase-3 wer...

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Detalhes bibliográficos
Main Authors: Chen, Jing-hong, Cao, Jun-ling, Chu, Yong-lie, Wang, Zhi-lun, Yang, Zhan-tian, Wang, Hong-lin
Formato: Artigo
Idioma:Inglês
Publicado em: Zhejiang University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408698/
https://ncbi.nlm.nih.gov/pubmed/18543398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B0820013
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