Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infiltrating CD8+ T cells in colon cancer. In humans suffering from colorectal cancer, TIM-3+ po...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kang, Chiao-Wen, Dutta, Avijit, Chang, Li-Yuan, Mahalingam, Jayashri, Lin, Yung-Chang, Chiang, Jy-Ming, Hsu, Chen-Yu, Huang, Ching-Tai, Su, Wan-Ting, Chu, Yu-Yi, Lin, Chun-Yen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616166/
https://ncbi.nlm.nih.gov/pubmed/26493689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15659
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