Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells

The expression of the epidermal growth factor receptor (EGFR) is highly regulated in normal cells, whereas some cancer cells have high constitutive levels. Understanding naturally-occurring ways of downregulating EGFR in cancer cells was investigated. Phosphatidic acid (PA) or Nuclear Receptors (NR)...

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Vydáno v:Sci Rep
Hlavní autoři: Mahankali, Madhu, Farkaly, Terry, Bedi, Shimpi, Hostetler, Heather A., Gomez-Cambronero, Julian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615983/
https://ncbi.nlm.nih.gov/pubmed/26493292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15379
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