Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Background: Obesity and hypertension are associated with increased leptin production contributing to cardiovascular remodeling. Mechanisms involving mechanical stretch-induced leptin production and the cross talk between signaling pathways leading to vascular remodeling have not been fully elucidate...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ghantous, Crystal M., Kobeissy, Firas H., Soudani, Nadia, Rahman, Farah A., Al-Hariri, Mustafa, Itani, Hana A., Sabra, Ramzi, Zeidan, Asad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615939/
https://ncbi.nlm.nih.gov/pubmed/26557089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00240
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