Calcineurin/NFAT Activation-Dependence of Leptin Synthesis and Vascular Growth in Response to Mechanical Stretch

Background and Aims: Hypertension and obesity are important risk factors of cardiovascular disease. They are both associated with high leptin levels and have been shown to promote vascular hypertrophy, through the RhoA/ROCK and ERK1/2 phosphorylation. Calcineurin/NFAT activation also induces vascula...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Soudani, Nadia, Ghantous, Crystal M., Farhat, Zein, Shebaby, Wassim N., Zibara, Kazem, Zeidan, Asad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040753/
https://ncbi.nlm.nih.gov/pubmed/27746739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00433
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