The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal and central domains (RRM1 and RRM2) are essential for AREs recognition, little is known on the C-terminal RRM3 beyond its implic...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Scheiba, Rafael M, de Opakua, Alain Ibáñez, Díaz-Quintana, Antonio, Cruz-Gallardo, Isabel, Martínez-Cruz, Luis A, Martínez-Chantar, María L, Blanco, Francisco J, Díaz-Moreno, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615805/
https://ncbi.nlm.nih.gov/pubmed/25584704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2014.996069
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