Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

The cell nucleus is structurally and functionally organized by lamins, intermediate filament proteins that form the nuclear lamina. Point mutations in genes that encode a specific subset of lamins, the A-type lamins, cause a spectrum of diseases termed laminopathies. Recent evidence points to a role...

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Detalhes bibliográficos
Publicado no:Nucleus
Main Authors: Sieprath, Tom, Corne, Tobias DJ, Nooteboom, Marco, Grootaert, Charlotte, Rajkovic, Andreja, Buysschaert, Benjamin, Robijns, Joke, Broers, Jos LV, Ramaekers, Frans CS, Koopman, Werner JH, Willems, Peter HGM, De Vos, Winnok H
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615646/
https://ncbi.nlm.nih.gov/pubmed/25996284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2015.1050568
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