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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice
BACKGROUND & AIMS: The inflammasome is a well-characterized inducer of inflammation in ASH. Inflammasome activation requires two signals for mature interleukin (IL)-1β production. Here we asked whether metabolic danger signals trigger inflammasome activation in ASH. METHODS: Wild-type mice, ATP...
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| Veröffentlicht in: | J Hepatol |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4615393/ https://ncbi.nlm.nih.gov/pubmed/26100496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.06.013 |
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