Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice

BACKGROUND & AIMS: The inflammasome is a well-characterized inducer of inflammation in ASH. Inflammasome activation requires two signals for mature interleukin (IL)-1β production. Here we asked whether metabolic danger signals trigger inflammasome activation in ASH. METHODS: Wild-type mice, ATP...

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Vydáno v:J Hepatol
Hlavní autoři: Iracheta-Vellve, Arvin, Petrasek, Jan, Satishchandran, Abhishek, Gyongyosi, Benedek, Saha, Banishree, Kodys, Karen, Fitzgerald, Katherine A., Kurt-Jones, Evelyn A., Szabo, Gyongyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615393/
https://ncbi.nlm.nih.gov/pubmed/26100496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.06.013
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