The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

BACKGROUND: While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour...

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Bibliographic Details
Published in:	J Exp Clin Cancer Res
Main Authors:	Wang, Ning, Reeves, Kimberley J., Brown, Hannah K., Fowles, Anne C M, Docherty, Freyja E., Ottewell, Penelope D., Croucher, Peter I., Holen, Ingunn, Eaton, Colby L.
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2015
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4615337/ https://ncbi.nlm.nih.gov/pubmed/26480944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0240-8
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The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

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