The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

BACKGROUND: While both preclinical and clinical studies suggest that the frequency of growing skeletal metastases is elevated in individuals with higher bone turnover, it is unclear whether this is a result of increased numbers of tumour cells arriving in active sites or of higher numbers of tumour...

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Pubblicato in:J Exp Clin Cancer Res
Autori principali: Wang, Ning, Reeves, Kimberley J., Brown, Hannah K., Fowles, Anne C M, Docherty, Freyja E., Ottewell, Penelope D., Croucher, Peter I., Holen, Ingunn, Eaton, Colby L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615337/
https://ncbi.nlm.nih.gov/pubmed/26480944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0240-8
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