Chromosome Conformation of Human Fibroblasts Grown in 3-Dimensional Spheroids

In the study of interphase chromosome organization, genome-wide chromosome conformation capture (Hi-C) maps are often generated using 2-dimensional (2D) monolayer cultures. These 2D cells have morphological deviations from cells that exist in 3-dimensional (3D) tissues in vivo, and may not maintain...

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Udgivet i:Nucleus
Main Authors: Chen, Haiming, Comment, Nicholas, Chen, Jie, Ronquist, Scott, Hero, Alfred, Ried, Thomas, Rajapakse, Indika
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615318/
https://ncbi.nlm.nih.gov/pubmed/25738643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2014.1003745
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