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Spectral identification of topological domains

Motivation: Topological domains have been proposed as the backbone of interphase chromosome structure. They are regions of high local contact frequency separated by sharp boundaries. Genes within a domain often have correlated transcription. In this paper, we present a computational efficient spectr...

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Publicat a:Bioinformatics
Autors principals: Chen, Jie, Hero, Alfred O., Rajapakse, Indika
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937202/
https://ncbi.nlm.nih.gov/pubmed/27153657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw221
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