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RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation
Site-specific hypermethylation of tumor suppressor genes accompanied by genome-wide hypomethylation are epigenetic hallmarks of malignancy. However, the molecular mechanisms that drive these linked changes in DNA methylation remain obscure. DNA methyltransferase 1 (DNMT1), the principle enzyme respo...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Cycle |
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| Κύριοι συγγραφείς: | , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4615144/ https://ncbi.nlm.nih.gov/pubmed/25485502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950886 |
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