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Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression
Down syndrome (DS) is caused by a triplication of chromosome 21 (HSA21). Increased oxidative stress, decreased neurogenesis and synaptic dysfunction from HSA21 gene overexpression are thought to cause mental retardation, dementia and seizure in this disorder. Recent epigenetic studies have raised th...
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| 出版年: | Hum Mol Genet |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4986328/ https://ncbi.nlm.nih.gov/pubmed/26911678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw043 |
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