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RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation
Site-specific hypermethylation of tumor suppressor genes accompanied by genome-wide hypomethylation are epigenetic hallmarks of malignancy. However, the molecular mechanisms that drive these linked changes in DNA methylation remain obscure. DNA methyltransferase 1 (DNMT1), the principle enzyme respo...
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| 出版年: | Cell Cycle |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4615144/ https://ncbi.nlm.nih.gov/pubmed/25485502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.950886 |
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