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Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding

RNA-DNA hybrids play essential roles in a variety of biological processes, including DNA replication, transcription, and viral integration. Ribonucleotides incorporated within DNA are hydrolyzed by RNase H enzymes in a removal process that is necessary for maintaining genomic stability. In order to...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Davis, Ryan R, Shaban, Nadine M, Perrino, Fred W, Hollis, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615118/
https://ncbi.nlm.nih.gov/pubmed/25664393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.994996
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