miR-214-mediated downregulation of RNF8 induces chromosomal instability in ovarian cancer cells

Defective DNA damage response (DDR) is frequently associated with carcinogenesis. Abrogation of DDR leads to chromosomal instability, a most common characteristic of tumors. However, the molecular mechanisms underlying regulation of DDR are still elusive. The ubiquitin ligase RNF8 mediates the ubiqu...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Cycle
Hauptverfasser: Wang, Zheng, Yin, Hao, Zhang, Yuanwei, Feng, Yukun, Yan, Zhaofeng, Jiang, Xiaohua, Bukhari, Ihtisham, Iqbal, Furhan, Cooke, Howard J, Shi, Qinghua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615040/
https://ncbi.nlm.nih.gov/pubmed/25483088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.958413
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