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Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models

The proton pump vacuolar (V)-ATPase is the driving force that mediates the concentration of cationic drugs (weak bases) in the late endosome-lysosome continuum; secondary cell reactions include the protracted transformation of enlarged vacuoles into autophagosomes. We used the inherently fluorescent...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Parks, Alexandre, Charest-Morin, Xavier, Boivin-Welch, Michael, Bouthillier, Johanne, Marceau, Francois
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614855/
https://ncbi.nlm.nih.gov/pubmed/26500823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.1314
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