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Common and specific effects of TIE2 mutations causing venous malformations

Venous malformations (VMs) are localized defects in vascular morphogenesis frequently caused by mutations in the gene for the endothelial tyrosine kinase receptor TIE2. Here, we report the analysis of a comprehensive collection of 22 TIE2 mutations identified in patients with VM, either as single am...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Nätynki, Marjut, Kangas, Jaakko, Miinalainen, Ilkka, Sormunen, Raija, Pietilä, Riikka, Soblet, Julie, Boon, Laurence M., Vikkula, Miikka, Limaye, Nisha, Eklund, Lauri
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614705/
https://ncbi.nlm.nih.gov/pubmed/26319232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv349
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