C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G(1)/S checkpoint

The bZIP transcription factor, C/EBPα is highly inducible by UVB and other DNA damaging agents in keratinocytes. C/EBPα-deficient keratinocytes fail to undergo cell cycle arrest in G(1) in response to UVB-induced DNA damage and mice lacking epidermal C/EBPα are highly susceptible to UVB-induced skin...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Hall, Jonathan R, Bereman, Michael S, Nepomuceno, Angelito I, Thompson, Elizabeth A, Muddiman, David C, Smart, Robert C
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614632/
https://ncbi.nlm.nih.gov/pubmed/25483090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.962957
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