Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging

The phase of the cell cycle can determine whether a cancer cell can respond to a given drug. We previously reported monitoring of real-time cell cycle dynamics of cancer cells throughout a live tumor, intravitally in live mice, using a fluorescence ubiquitination-based cell-cycle indicator (FUCCI)....

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Vydáno v:Cell Cycle
Hlavní autoři: Yano, Shuya, Miwa, Shinji, Mii, Sumiyuki, Hiroshima, Yukihiko, Uehara, Fuminaru, Kishimoto, Hiroyuki, Tazawa, Hiroshi, Zhao, Ming, Bouvet, Michael, Fujiwara, Toshiyoshi, Hoffman, Robert M
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614530/
https://ncbi.nlm.nih.gov/pubmed/25564963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2014.1000685
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