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IDH mutations in liver cell plasticity and biliary cancer

Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer associated with the bile ducts within the liver. These tumors are characterized by frequent gain-of-function mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes—that are also common in subsets of neural, haematopoietic...

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Pubblicato in:Cell Cycle
Autori principali: Saha, Supriya K, Parachoniak, Christine A, Bardeesy, Nabeel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614372/
https://ncbi.nlm.nih.gov/pubmed/25485496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.965054
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