Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer’s Disease (AD) but the underlying mechanisms have not been fully elucidated yet. Here we demonstrate that in cultured mouse cortical neurons HSV-1 induced Ca(...

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Published in:Sci Rep
Main Authors: Piacentini, Roberto, Li Puma, Domenica Donatella, Ripoli, Cristian, Elena Marcocci, Maria, De Chiara, Giovanna, Garaci, Enrico, Teresa Palamara, Anna, Grassi, Claudio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614347/
https://ncbi.nlm.nih.gov/pubmed/26487282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15444
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