De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins

Stem cells have a peculiar chromatin architecture that contributes to their unique properties, including uncommitted status, multi/pluripotency and self-renewal. We analyzed the effect of the de-regulation of the SWI/SNF chromatin remodeling complex in mesenchymal stromal cells (MSC) through the sil...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Squillaro, Tiziana, Severino, Valeria, Alessio, Nicola, Farina, Annarita, Di Bernardo, Giovanni, Cipollaro, Marilena, Peluso, Gianfranco, Chambery, Angela, Galderisi, Umberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614278/
https://ncbi.nlm.nih.gov/pubmed/25724006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.995053
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