Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells

Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realiz...

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Detalhes bibliográficos
Main Authors: Severino, V, Alessio, N, Farina, A, Sandomenico, A, Cipollaro, M, Peluso, G, Galderisi, U, Chambery, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847322/
https://ncbi.nlm.nih.gov/pubmed/24201810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.445
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