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Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers

Histone deacetylases 1 and 2 (HDAC1,2) belong to the class I HDAC family, which are targeted by the FDA-approved small molecule HDAC inhibitors currently used in cancer therapy. HDAC1,2 are recruited to DNA break sites during DNA repair and to chromatin around forks during DNA replication. Cancer ce...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Cell Cycle
1. autor: Bhaskara, Srividya
Format: Artigo
Język:Inglês
Wydane: Taylor & Francis 2015
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614045/
https://ncbi.nlm.nih.gov/pubmed/25942572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1042634
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