Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Distinct stressors may induce heart failure. As compensation, β-adrenergic stimulation enhances myocardial contractility by elevating cardiomyocyte intracellular Ca(2+) ([Ca(2+)](i)). However, chronic β-adrenergic stimulation promotes adverse cardiac remodelling. Cardiac expression of nuclear recept...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Medzikovic, Lejla, Schumacher, Cees A., Verkerk, Arie O., van Deel, Elza D., Wolswinkel, Rianne, van der Made, Ingeborg, Bleeker, Natascha, Cakici, Daniella, van den Hoogenhof, Maarten M. G., Meggouh, Farid, Creemers, Esther E., Ann Remme, Carol, Baartscheer, Antonius, de Winter, Robbert J., de Vries, Carlie J. M., Arkenbout, E. Karin, de Waard, Vivian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613907/
https://ncbi.nlm.nih.gov/pubmed/26486271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15404
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