Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Distinct stressors may induce heart failure. As compensation, β-adrenergic stimulation enhances myocardial contractility by elevating cardiomyocyte intracellular Ca(2+) ([Ca(2+)](i)). However, chronic β-adrenergic stimulation promotes adverse cardiac remodelling. Cardiac expression of nuclear recept...

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Publicat a:Sci Rep
Autors principals: Medzikovic, Lejla, Schumacher, Cees A., Verkerk, Arie O., van Deel, Elza D., Wolswinkel, Rianne, van der Made, Ingeborg, Bleeker, Natascha, Cakici, Daniella, van den Hoogenhof, Maarten M. G., Meggouh, Farid, Creemers, Esther E., Ann Remme, Carol, Baartscheer, Antonius, de Winter, Robbert J., de Vries, Carlie J. M., Arkenbout, E. Karin, de Waard, Vivian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613907/
https://ncbi.nlm.nih.gov/pubmed/26486271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15404
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