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Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at stalled forks

While it has been widely established that defective fork restart after exposure to stress results in increased genomic instability, the importance of fork protection during stalling for safeguarding genomic integrity has recently been fully appreciated. BRCA2, Breast tumor suppressor, has dual funct...

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Publicado en:Cell Cycle
Main Authors: Pefani, Dafni Eleftheria, O'Neill, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613848/
https://ncbi.nlm.nih.gov/pubmed/25927241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1035845
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