RASSF1A-LATS1 signalling stabilises replication forks by restricting CDK2-mediated phosphorylation of BRCA2

Genomic instability is a key hallmark of cancer leading to tumour heterogeneity and therapeutic resistance. BRCA2 has a fundamental role in error-free DNA repair but additionally sustains genome integrity by promoting RAD51 nucleofilament formation at stalled replication forks. CDK2 phosphorylates B...

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Publicat a:Nat Cell Biol
Autors principals: Pefani, Dafni-Eleftheria, Latusek, Robert, Pires, Isabel, Grawenda, Anna M., Yee, Karen S., Hamilton, Garth, van der Weyden, Louise, Esashi, Fumiko, Hammond, Ester M., O’Neill, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861244/
https://ncbi.nlm.nih.gov/pubmed/25218637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3035
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